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KMID : 0191120170320081268
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Journal of Korean Medical Science
2017 Volume.32 No. 8 p.1268 ~ p.1274
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Metabolic Complications among Korean Patients with HIV Infection: The Korea HIV/AIDS Cohort Study
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Oh Dong-Hyun
Ahn Jin-Young
Kim Sang-Il
Kim Min-Ja
Woo Jun-Hee
Kim Woo-Joo
Baek Ji-Hyeon
Kim Shin-Woo
Choi Bo-Youl
Lee Mi-Hwa
Choi Ju-Yeon
Han Myung-Guk
Kang Chun
Kim June-Myung
Choi Jun-Yong
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Abstract
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Currently, metabolic complications are the most common problem among human immunodeficiency virus (HIV)-infected patients, with a high incidence. However, there have been very few studies regarding metabolic abnormalities published in Asia, especially in Korea. This cross-sectional study was performed to investigate the prevalence of and risk factors for metabolic abnormalities in 1,096 HIV-infected patients of the Korea HIV/AIDS cohort study enrolled from 19 hospitals between 2006 and 2013. Data at entry to cohort were analyzed. As a result, the median age of the 1,096 enrolled subjects was 46 years, and most patients were men (92.8%). The metabolic profiles of the patients were as follows: median weight was 63.8 kg, median body mass index (BMI) was 22.2 kg/m2, and 16.4% of the patients had a BMI over 25 kg/m2. A total of 5.5% of the patients had abdominal obesity (waist/hip ratio ≥ 1 in men, ≥ 0.85 in women). Increased levels of fasting glucose, total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides were present in 10.4%, 6.0%, 5.5%, and 32.1% of the patients. Decreased high-density lipoprotein (HDL) cholesterol levels were observed in 44.2% of the patients. High systolic blood pressure was present in 14.3% of the patients. In multivariate analysis, high BMI and the use of protease inhibitors (PIs) were risk factors for dyslipidemia in HIV-infected patients. In conclusion, proper diagnosis and management should be offered for the prevalent metabolic complications of Korean HIV-infected patients. Further studies on risk factors for metabolic complications are needed.
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KEYWORD
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HIV Infection, Metabolic Complication, Dyslipidemia, Protease Inhibitor
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